Myocardial injury is one of the important pathogenic features of COVID-19. There is growing literature exploring cardiac involvement in SARS-CoV-2. Hypertension, arrhythmia, cardiomyopathy and coronary heart disease are amongst major cardiovascular disease comorbidities seen in severe cases of COVID-19. Patients with cardiovascular disease are more likely to be infected with SARS-CoV-2 and they are more likely to develop severe symptoms. Disruption of this receptor leads to cardiomyopathy, cardiac dysfunction, and heart failure. Angiotensin Converting Enzyme-2 receptors play a pivotal role in the pathogenesis of the virus. There is growing evidence describing pathophysiological resemblance of SARS-CoV-2 infection with other coronavirus infections such as Severe Acute Respiratory Syndrome coronavirus and Middle East Respiratory Syndrome coronavirus (MERS-CoV). Respiratory illness is the major cause of morbidity and mortality in these patients with the disease spectrum ranging from asymptomatic subclinical infection, to severe pneumonia progressing to acute respiratory distress syndrome. Coronavirus Disease 2019 (COVID-19) has quickly progressed to a global health emergency.
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